Anti-SLC39A5 antibody

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:500-2000 ELISA 1:5000-20000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	SLC39A5
Gene ID:	283375
Uniprot ID:	S39A5_HUMAN
Specificity:	S39A5 Polyclonal Antibody detects endogenous levels of protein.
Immunogen:	Synthesized peptide derived from part of the human protein

Post Translational Modifications	Methylated at His-375 by METTL9. N-Glycosylated.
Function	Uniporter that transports zinc(2+) into polarized cells of enterocytes, pancreatic acinar and endoderm cells across the basolateral membrane and participates, notably, in zinc excretion from the intestine by the uptake of zinc from the blood into the intestine. The transport mechanism is temperature- and concentration-dependent and saturable. In addition, is also a high affinity copper transporter in vitro. Also may regulate glucose-stimulated insulin secretion (GSIS) in islets primarily through the zinc-activated SIRT1-PPARGC1A axis. Could regulate the BMP/TGF-beta (bone morphogenetic protein/transforming growth factor-beta) signaling pathway and modulates extracellular matrix (ECM) proteins of the sclera. Plays a role in eye development.
Protein Name	Zinc Transporter Zip5 Solute Carrier Family 39 Member 5 Zrt- And Irt-Like Protein 5 Zip-5
Database Links	Reactome: R-HSA-442380
Cellular Localisation	Basolateral Cell Membrane Multi-Pass Membrane Protein Localized To The Basolateral Surfaces Of Enterocytes Pancreatic Acinar And Endoderm Cells During Zinc Deficiency Diet The Basolateral Cell Membrane Localization Is Lost In The Intestine The Visceral Yolk Sac And Acinar Cell During Zinc Repletion Is Relocalized To The Basolateral Membrane Of Enterocytes Visceral Endoderm Cells And Pancreatic Acinar Cells Zinc Can Regulate The Turnover Of Protein At The Membrane During Zinc Deficiency Is Internalized And Degraded In Enterocytes Acinar Cells And Endoderm Cells Endocytosed Through The Endolysosomal Degradation Pathway Rab5a Pathway
Alternative Antibody Names	Anti-Zinc Transporter Zip5 antibody Anti-Solute Carrier Family 39 Member 5 antibody Anti-Zrt- And Irt-Like Protein 5 antibody Anti-Zip-5 antibody Anti-SLC39A5 antibody Anti-ZIP5 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance