Anti-CXCR3 antibody (1-50) {FITC}

Clonality:	Polyclonal
Conjugation:	FITC
Isotype:	IgG
Purification:	Affinity Purified
Concentration:	0.50-0.60 µg/µl
Dilution Range:	WB: 1:500 DB: 1:10, 000 ELISA: 1:10, 000 IP: 1:250 IHC: 1:200 ICC: 1:200 IF: 1:200 CFM: 1:200
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	CXCR3
Gene ID:	2833
Uniprot ID:	CXCR3_HUMAN
Immunogen Region:	1-50
Immunogen:	Synthetic peptide taken within amino acid region 1-50 on human CXCR3 protein.

Post Translational Modifications	Sulfation on Tyr-27 and Tyr-29 is essential for CXCL10 binding and subsequent signal transduction induction. N-glycosylated.
Function	Isoform 1: Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of human mesangial cells (HMC) through a heterotrimeric G-protein signaling pathway. Binds to CCL21. Probably promotes cell chemotaxis response. Isoform 2: Receptor for the C-X-C chemokine CXCL4 and also mediates the inhibitory activities of CXCL9, CXCL10 and CXCL11 on the proliferation, survival and angiogenic activity of human microvascular endothelial cells (HMVEC) through a cAMP-mediated signaling pathway. Does not promote cell chemotaxis respons. Interaction with CXCL4 or CXCL10 leads to activation of the p38MAPK pathway and contributes to inhibition of angiogenesis. Overexpression in renal cancer cells down-regulates expression of the anti-apoptotic protein HMOX1 and promotes apoptosis. Isoform 3: Mediates the activity of CXCL11.
Protein Name	C-X-C Chemokine Receptor Type 3 Cxc-R3 Cxcr-3 Ckr-L2 G Protein-Coupled Receptor 9 Interferon-Inducible Protein 10 Receptor Ip-10 Receptor Cd Antigen Cd183
Database Links	Reactome: R-HSA-380108 Reactome: R-HSA-418594
Cellular Localisation	Isoform 1: Cell Membrane Multi-Pass Membrane Protein Isoform 2: Cell Membrane
Alternative Antibody Names	Anti-C-X-C Chemokine Receptor Type 3 antibody Anti-Cxc-R3 antibody Anti-Cxcr-3 antibody Anti-Ckr-L2 antibody Anti-G Protein-Coupled Receptor 9 antibody Anti-Interferon-Inducible Protein 10 Receptor antibody Anti-Ip-10 Receptor antibody Anti-Cd Antigen Cd183 antibody Anti-CXCR3 antibody Anti-GPR9 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance