General Info
| Host: | Mouse |
| Applications: | IHC-F/IHC-P/FC/WB |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Mouse monoclonal antibody anti-HCAM is suitable for use in Immunohistochemistry, Flow Cytometry and Western Blot research applications. |
| Clonality: | Monoclonal |
| Clone ID: | DF 1485 |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Formulation: | Contains 0.09% sodium azide |
| Dilution Range: | IHC-FIHC-P 1:5-1:10FCWB |
| Storage Instruction: | Store at 2-8°C upon receipt. |
Information
| Immunogen: | CD44 antigen (PGp-1) purified from lymphocyte membrane |
Description
| Background | CD44 (HCAM) is a transmembrane protein expressed by lymphocytes, erythrocytes and several normal epithelial cells and is a member of the CAM family. It is involved in lymphocyte homing, T-lymphocyte activation, interaction with hyaluronic acid and may act as an adhesion molecule. The human CD44 is composed of 19 exons, 9 variably expressed due to alternative splicing of mRNA; RT CD44 (CD44s) is composed of exons 1-5 and 15-19. The loss of CD44s expression predicts unfavorable outcome in bladder cancers, squamous cell carcinomas of the skin, prostatic adenocarcinoma and neuroblastomas. In immunoblotting the antibody reacts with a glycoprotein isolated from hematopoetic cells and epithelial cells with a respective molecular weight of 29-37 kD and 51 kD. Positive control: Tonsil (cell membrane staining). |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance