General Info
Host: | Mouse |
Applications: | FC |
Reactivity: | Human |
Note: | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Short Description: | Mouse monoclonal antibody anti-CD9 antigen is suitable for use in Flow Cytometry research applications. |
Clonality: | Monoclonal |
Clone ID: | HI9a |
Conjugation: | PerCP/Cyanine5.5 |
Isotype: | IgG1k |
Formulation: | PBS with 0.05% Proclin300, 1% BSA |
Storage Instruction: | Recommend storing between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product. |
Information
Description
Tissue Specificity | Detected in platelets (at protein level). Expressed by a variety of hematopoietic and epithelial cells. |
Post Translational Modifications | Palmitoylated at a low, basal level in unstimulated platelets. The level of palmitoylation increases when platelets are activated by thrombin (in vitro). The protein exists in three forms with molecular masses between 22 and 27 kDa, and is known to carry covalently linked fatty acids. Palmitoylation by ZDHHC2 regulates CD9 expression, association with other tetraspanin family proteins and function in cell adhesion. |
Function | Integral membrane protein associated with integrins, which regulates different processes, such as sperm-egg fusion, platelet activation and aggregation, and cell adhesion. Present at the cell surface of oocytes and plays a key role in sperm-egg fusion, possibly by organizing multiprotein complexes and the morphology of the membrane required for the fusion. In myoblasts, associates with CD81 and PTGFRN and inhibits myotube fusion during muscle regeneration. In macrophages, associates with CD81 and beta-1 and beta-2 integrins, and prevents macrophage fusion into multinucleated giant cells specialized in ingesting complement-opsonized large particles. Also prevents the fusion between mononuclear cell progenitors into osteoclasts in charge of bone resorption. Acts as a receptor for PSG17. Involved in platelet activation and aggregation. Regulates paranodal junction formation. Involved in cell adhesion, cell motility and tumor metastasis. |
Protein Name | Cd9 Antigen 5h9 Antigen Cell Growth-Inhibiting Gene 2 Protein Leukocyte Antigen Mic3 Motility-Related Protein Mrp-1 Tetraspanin-29 Tspan-29 P24 Cd Antigen Cd9 |
Database Links | Reactome: R-HSA-114608 Reactome: R-HSA-1300645 Reactome: R-HSA-5336415 |
Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein Membrane Secreted Extracellular Exosome Present At The Cell Surface Of Oocytes Accumulates In The Adhesion Area Between The Sperm And Egg Following Interaction Between Izumo1 And Its Receptor Izumo1r/Juno |
Alternative Antibody Names | Anti-Cd9 Antigen antibody Anti-5h9 Antigen antibody Anti-Cell Growth-Inhibiting Gene 2 Protein antibody Anti-Leukocyte Antigen Mic3 antibody Anti-Motility-Related Protein antibody Anti-Mrp-1 antibody Anti-Tetraspanin-29 antibody Anti-Tspan-29 antibody Anti-P24 antibody Anti-Cd Antigen Cd9 antibody Anti-CD9 antibody Anti-MIC3 antibody Anti-TSPAN29 antibody Anti-GIG2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance