Anti-PHB2 antibody (1-299)

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000 IHC-P 1:50-1:100 IP 1:500-1:1000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	PHB2
Gene ID:	11331
Uniprot ID:	PHB2_HUMAN
Immunogen Region:	1-299
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-299 of human Prohibitin 2 (Prohibitin 2 (PHB2) ) (NP_001138303.1).
Immunogen Sequence:	MAQNLKDLAGRLPAGPRGMG TALKLLLGAGAVAYGVRESV FTVEGGHRAIFFNRIGGVQQ DTILAEGLHFRIPWFQYPII YDIRARPRKISSPTGSKDLQ MVNISLRVLSRPNAQELPSM YQRLGLDYEERVLPSIVNEV LKSVVAKFNASQLITQRAQV SLLIRRELTERAKDFSLILD DVAITELSFSREYTAAVEAK QVAQQEAQRAQFLVEKAKQE QRQKIVQAEGEAEAAKMLG

Post Translational Modifications	Phosphorylated. Tyrosine phosphorylation is indirectly stimulated by IGFBP6.
Function	Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors and sex steroid hormones in the nucleus. In the mitochondria, together with PHB, forms large ring complexes (prohibitin complexes) in the inner mitochondrial membrane (IMM) and functions as chaperone protein that stabilizes mitochondrial respiratory enzymes and maintains mitochondrial integrity in the IMM, which is required for mitochondrial morphogenesis, neuronal survival, and normal lifespan (Probable). The prohibitin complex, with DNAJC19, regulates cardiolipin remodeling and the protein turnover of OMA1 in a cardiolipin-binding manner. Also regulates cytochrome-c oxidase assembly (COX) and mitochondrial respiration. Binding to sphingoid 1-phosphate (SPP) modulates its regulator activity. Has a key role of mitophagy receptor involved in targeting mitochondria for autophagic degradation. Involved in mitochondrial-mediated antiviral innate immunity, activates RIG-I-mediated signal transduction and production of IFNB1 and pro-inflammatory cytokine IL6. In the nucleus, serves as transcriptional co-regulator (Probable). Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. In the plasma membrane, is involved in IGFBP6-induced cell migration. Cooperates with CD86 to mediate CD86-signaling in B lymphocytes that regulates the level of IgG1 produced through the activation of distal signaling intermediates. Upon CD40 engagement, required to activate NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation. (Microbial infection) Involved in human enterovirus 71/EV-71 infection by enhancing the autophagy mechanism during the infection.
Protein Name	Prohibitin-2 B-Cell Receptor-Associated Protein Bap37 D-Prohibitin Repressor Of Estrogen Receptor Activity
Database Links	Reactome: R-HSA-8949664
Cellular Localisation	Mitochondrion Inner Membrane Cytoplasm Nucleus Cell Membrane Isoform 1: Mitochondrion Inner Membrane Isoform 2: Mitochondrion Inner Membrane
Alternative Antibody Names	Anti-Prohibitin-2 antibody Anti-B-Cell Receptor-Associated Protein Bap37 antibody Anti-D-Prohibitin antibody Anti-Repressor Of Estrogen Receptor Activity antibody Anti-PHB2 antibody Anti-BAP antibody Anti-REA antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance