Rat a2M (Alpha-2-Macroglobulin) Sandwich ELISA Kit

Storage Instruction:	Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	4.5 hrs

Gene Symbol:	A2m
Gene ID:	24153
Uniprot ID:	A2MG_RAT
Sample Type:	serum, plasma, urine or other biological fluids.

Tissue Specificity	Highest constitutive expression in ovary. Low level in testis, uterus and non-acute phase liver. Protein found in plasma.
Post Translational Modifications
Function	Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
Protein Name	Alpha-2-Macroglobulin Alpha-2-M
Database Links	Reactome: R-RNO-114608 Reactome: -RNO-140837 Reactome: -RNO-1474228 Reactome: -RNO-8963896
Cellular Localisation	Secreted
Alternative ELISA Names	Alpha-2-Macroglobulin ELISA kit Alpha-2-M ELISA kit A2m ELISA kit A2m1 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance