General Info
| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Monkey |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-Acetyl-Histone H1.8-K25 (131-180 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:20000IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Information
| Gene Symbol: | H1-8 |
| Gene ID: | 132243 |
| Uniprot ID: | H18_HUMAN |
| Immunogen Region: | 131-180 aa |
| Specificity: | Acetyl-Histone H1 (K25) Polyclonal Antibody detects endogenous levels of Histone H1 protein only when acetylated at K25. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human Histone H1 around the acetylated site of Lys25 at the amino acid range 131-180 |
Description
| Function | May play a key role in the control of gene expression during oogenesis and early embryogenesis, presumably through the perturbation of chromatin structure. Essential for meiotic maturation of germinal vesicle-stage oocytes. The somatic type linker histone H1c is rapidly replaced by H1oo in a donor nucleus transplanted into an oocyte. The greater mobility of H1oo as compared to H1c may contribute to this rapid replacement and increased instability of the embryonic chromatin structure. The rapid replacement of H1c with H1oo may play an important role in nuclear remodeling. |
| Protein Name | Histone H1.8Histone H1ooOocyte-Specific Histone H1Oocyte-Specific Linker Histone H1Osh1 |
| Cellular Localisation | CytoplasmNucleusChromosome |
| Alternative Antibody Names | Anti-Histone H1.8 antibodyAnti-Histone H1oo antibodyAnti-Oocyte-Specific Histone H1 antibodyAnti-Oocyte-Specific Linker Histone H1 antibodyAnti-Osh1 antibodyAnti-H1-8 antibodyAnti-H1FOO antibodyAnti-H1OO antibodyAnti-OSH1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance