General Info
Host: | Mouse |
Applications: | FC |
Reactivity: | Human |
Note: | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Short Description: | Mouse monoclonal antibody anti-T-lymphocyte activation antigen CD86 is suitable for use in Flow Cytometry research applications. |
Clonality: | Monoclonal |
Clone ID: | BU63 |
Conjugation: | AF647 |
Isotype: | IgG1k |
Formulation: | PBS with 0.05% Proclin300, 1% BSA |
Storage Instruction: | Recommend storing between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product. |
Information
Gene Symbol: | CD86 |
Gene ID: | 942 |
Uniprot ID: | CD86_HUMAN |
Description
Tissue Specificity | Expressed by activated B-lymphocytes and monocytes. |
Post Translational Modifications | Polyubiquitinated.which is promoted by MARCH8 and results in endocytosis and lysosomal degradation. |
Function | Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Also involved in the regulation of B cells function, plays a role in regulating the level of IgG(1) produced. Upon CD40 engagement, activates NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation. Isoform 2: Interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation. (Microbial infection) Acts as a receptor for adenovirus subgroup B. |
Protein Name | T-Lymphocyte Activation Antigen Cd86 Activation B7-2 Antigen B70 Bu63 Ctla-4 Counter-Receptor B7.2 Fun-1 Cd Antigen Cd86 |
Database Links | Reactome: R-HSA-1257604 Reactome: R-HSA-2219530 Reactome: R-HSA-389356 Reactome: R-HSA-389357 Reactome: R-HSA-389359 Reactome: R-HSA-389513 Reactome: R-HSA-6783783 Reactome: R-HSA-6811558 |
Cellular Localisation | Cell Membrane Single-Pass Type I Membrane Protein |
Alternative Antibody Names | Anti-T-Lymphocyte Activation Antigen Cd86 antibody Anti-Activation B7-2 Antigen antibody Anti-B70 antibody Anti-Bu63 antibody Anti-Ctla-4 Counter-Receptor B7.2 antibody Anti-Fun-1 antibody Anti-Cd Antigen Cd86 antibody Anti-CD86 antibody Anti-CD28LG2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance