Anti-DSTYK antibody (200-250) {FITC}

Clonality:	Polyclonal
Conjugation:	FITC
Isotype:	IgG
Purification:	Affinity Purified
Concentration:	0.55 µg/µl
Dilution Range:	WB: 1:500 DB: 1:10, 000 ELISA: 1:10, 000 IP: 1:150
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	DSTYK
Gene ID:	25778
Uniprot ID:	DUSTY_HUMAN
Immunogen Region:	200-250
Immunogen:	Synthetic peptide taken within amino acid region 200-250 on human Dual serine/threonine and tyrosine protein kinase protein (RIPK5).

Tissue Specificity	Predominantly expressed in skeletal muscle and testis. Expressed in basolateral and apical membranes of all tubular epithelia. Expressed in thin ascending limb of the loop of Henle and the distal convoluted tubule. Expressed in all layers of transitional ureteric epithelium and in the ureteric smooth-muscle cells. Weakly expressed in heart, brain, placenta, kidney, pancreas, spleen, thymus, prostate, uterus, small intestine, white blood cells, stomach, spinal cord and adrenal gland. Is widely distributed in the CNS. Also detected in several tumor cell lines. Expressed in the skin.
Function	Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. Involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death. In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types.
Protein Name	Dual Serine/Threonine And Tyrosine Protein Kinase Dusty Protein Kinase Dusty Pk Rip-Homologous Kinase Receptor-Interacting Serine/Threonine-Protein Kinase 5 Sugen Kinase 496 Sgk496
Cellular Localisation	Cytoplasm Cell Membrane Apical Cell Membrane Basolateral Cell Membrane Cell Junction Detected At Apical Cell-Cell Junctions Colocalized With Fgf Receptors To The Cell Membrane Detected In Basolateral And Apical Membranes Of All Tubular Epithelia
Alternative Antibody Names	Anti-Dual Serine/Threonine And Tyrosine Protein Kinase antibody Anti-Dusty Protein Kinase antibody Anti-Dusty Pk antibody Anti-Rip-Homologous Kinase antibody Anti-Receptor-Interacting Serine/Threonine-Protein Kinase 5 antibody Anti-Sugen Kinase 496 antibody Anti-Sgk496 antibody Anti-DSTYK antibody Anti-KIAA0472 antibody Anti-RIP5 antibody Anti-RIPK5 antibody Anti-SGK496 antibody Anti-HDCMD38P antibody

Information sourced from Uniprot.org

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