General Info
| Host: | Mouse |
| Applications: | WB/IHC/IF/FC/ELISA |
| Reactivity: | Human/Mouse/Monkey |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Mouse monoclonal antibody anti-Rapamycin-insensitive companion of mTOR is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence, Flow Cytometry and ELISA research applications. |
| Clonality: | Monoclonal |
| Clone ID: | 7B3 |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Formulation: | Liquid in PBS containing 0.03% Sodium Azide, 0.5% BSA, 50% Glycerol. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:2000IHC 1:200-1:1000IF 1:200-1:1000FC 1:200-1:400ELISA 1:10000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Information
| Gene Symbol: | RICTOR |
| Gene ID: | 253260 |
| Uniprot ID: | RICTR_HUMAN |
| Specificity: | Rictor Monoclonal Antibody detects endogenous levels of Rictor protein. |
| Immunogen: | Purified recombinant fragment of human Rictor expressed in E. Coli. |
Description
| Function | Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays an essential role in embryonic growth and development. |
| Protein Name | Rapamycin-Insensitive Companion Of MtorAvo3 HomologHavo3 |
| Database Links | Reactome: R-HSA-1257604Reactome: R-HSA-389357Reactome: R-HSA-5218920Reactome: R-HSA-5674400Reactome: R-HSA-6804757 |
| Alternative Antibody Names | Anti-Rapamycin-Insensitive Companion Of Mtor antibodyAnti-Avo3 Homolog antibodyAnti-Havo3 antibodyAnti-RICTOR antibodyAnti-KIAA1999 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance