Anti-CD95/FAS antibody (Clone: DX2) {APC}

Clonality:	Monoclonal
Clone ID:	DX2
Conjugation:	APC
Isotype:	IgG1k
Formulation:	PBS with 0.05% Proclin300, 1% BSA
Storage Instruction:	Recommend storing between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product.

Gene Symbol:	FAS
Gene ID:	355
Uniprot ID:	TNR6_HUMAN

Tissue Specificity	Isoform 1 and isoform 6 are expressed at equal levels in resting peripheral blood mononuclear cells. After activation there is an increase in isoform 1 and decrease in the levels of isoform 6.
Post Translational Modifications	(Microbial infection) Glycosylated at Arg-250 by enteropathogenic E.coli protein NleB1: arginine GlcNAcylation prevents homotypic/heterotypic death domain interactions. Palmitoylated. Palmitoylation by ZDHHC7 prevents the lysosomal degradation of FAS regulating its expression at the plasma membrane. N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.
Function	Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).
Protein Name	Tumor Necrosis Factor Receptor Superfamily Member 6 Apo-1 Antigen Apoptosis-Mediating Surface Antigen Fas Faslg Receptor Cd Antigen Cd95
Database Links	Reactome: R-HSA-140534 Reactome: R-HSA-3371378 Reactome: R-HSA-5213460 Reactome: R-HSA-5218900 Reactome: R-HSA-6803211 Reactome: R-HSA-69416 Reactome: R-HSA-75157
Cellular Localisation	Isoform 1: Cell Membrane Single-Pass Type I Membrane Protein Membrane Raft Isoform 2: Secreted Isoform 3: Secreted Isoform 4: Secreted Isoform 5: Secreted Isoform 6: Secreted
Alternative Antibody Names	Anti-Tumor Necrosis Factor Receptor Superfamily Member 6 antibody Anti-Apo-1 Antigen antibody Anti-Apoptosis-Mediating Surface Antigen Fas antibody Anti-Faslg Receptor antibody Anti-Cd Antigen Cd95 antibody Anti-FAS antibody Anti-APT1 antibody Anti-FAS1 antibody Anti-TNFRSF6 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance