General Info
| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-Cyclin-dependent kinase 12 (50-130 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000ELISA 1:5000-20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Information
| Gene Symbol: | CDK12 |
| Gene ID: | 51755 |
| Uniprot ID: | CDK12_HUMAN |
| Immunogen Region: | 50-130 aa |
| Specificity: | CDK12 Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: | Synthesized peptide derived from the human protein at the amino acid range 50-130 |
Description
| Post Translational Modifications | Phosphorylation at Thr-893 increases kinase activity. |
| Function | Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors. |
| Protein Name | Cyclin-Dependent Kinase 12Cdc2-Related Kinase - Arginine/Serine-RichCrkrsCell Division Cycle 2-Related Protein Kinase 7Cdc2-Related Protein Kinase 7Cell Division Protein Kinase 12Hcdk12 |
| Database Links | Reactome: R-HSA-6796648 |
| Cellular Localisation | NucleusNucleus SpeckleColocalized With Nuclear Speckles Throughout Interphase |
| Alternative Antibody Names | Anti-Cyclin-Dependent Kinase 12 antibodyAnti-Cdc2-Related Kinase - Arginine/Serine-Rich antibodyAnti-Crkrs antibodyAnti-Cell Division Cycle 2-Related Protein Kinase 7 antibodyAnti-Cdc2-Related Protein Kinase 7 antibodyAnti-Cell Division Protein Kinase 12 antibodyAnti-Hcdk12 antibodyAnti-CDK12 antibodyAnti-CRK7 antibodyAnti-CRKRS antibodyAnti-KIAA0904 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance