Anti-KRT20 antibody (300-350) {Biotin}

Clonality:	Polyclonal
Conjugation:	Biotin
Isotype:	IgG
Purification:	Affinity Purified
Concentration:	0.55-0.75 µg/µl
Dilution Range:	WB: 1:500 DB: 1:10, 000 ELISA: 1:10, 000 IP: 1:150
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	KRT20
Gene ID:	54474
Uniprot ID:	K1C20_HUMAN
Immunogen Region:	300-350
Immunogen:	Synthetic peptide taken within amino acid region 300-350 human keratin, type I cytoskeletal 20 protein.

Tissue Specificity	Expressed predominantly in the intestinal epithelium. Expressed in luminal cells of colonic mucosa. Also expressed in the Merkel cells of keratinized oral mucosa.specifically at the tips of some rete ridges of the gingival mucosa, in the basal layer of the palatal mucosa and in the taste buds of lingual mucosa.
Post Translational Modifications	Hyperphosphorylation at Ser-13 occurs during the early stages of apoptosis but becomes less prominent during the later stages. Phosphorylation at Ser-13 also increases in response to stress brought on by cell injury. Proteolytically cleaved by caspases during apoptosis. Cleavage occurs at Asp-228.
Function	Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, plays a role in the secretion of mucin in the small intestine.
Protein Name	Keratin - Type I Cytoskeletal 20 Cytokeratin-20 Ck-20 Keratin-20 K20 Protein It
Database Links	Reactome: R-HSA-6805567 Reactome: R-HSA-6809371
Cellular Localisation	Cytoplasm
Alternative Antibody Names	Anti-Keratin - Type I Cytoskeletal 20 antibody Anti-Cytokeratin-20 antibody Anti-Ck-20 antibody Anti-Keratin-20 antibody Anti-K20 antibody Anti-Protein It antibody Anti-KRT20 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance