General Info
Host: | Mouse |
Applications: | FC |
Reactivity: | Pig/Human/Dog |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Mouse monoclonal antibody anti-CD44 is suitable for use in Flow Cytometry research applications. |
Clonality: | Monoclonal |
Clone ID: | MEM-263 |
Conjugation: | PE |
Isotype: | IgG1 |
Formulation: | Stabilizing phosphate buffered saline (PBS) solution containing 15 mM sodium azide |
Storage Instruction: | Store at 2-8°C upon receipt. |
Information
Gene Symbol: | CD44 |
Gene ID: | 960 |
Uniprot ID: | CD44_HUMAN |
Immunogen: | COS-7 cells (African Green Monkey). |
Description
Tissue Specificity | Detected in fibroblasts and urine (at protein level). Detected in placenta (at protein level). Isoform 10 (epithelial isoform) is expressed by cells of epithelium and highly expressed by carcinomas. Expression is repressed in neuroblastoma cells. |
Post Translational Modifications | Proteolytically cleaved in the extracellular matrix by specific proteinases (possibly MMPs) in several cell lines and tumors. N-glycosylated. O-glycosylated.contains chondroitin sulfate glycans which can be more or less sulfated and whose number may affect the accessibility of specific proteinases to their cleavage site(s). It is uncertain if O-glycosylation occurs on Thr-637 or Thr-638. Phosphorylated.activation of PKC results in the dephosphorylation of Ser-706 (constitutive phosphorylation site), and the phosphorylation of Ser-672. |
Function | Cell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment. Participates thereby in a wide variety of cellular functions including the activation, recirculation and homing of T-lymphocytes, hematopoiesis, inflammation and response to bacterial infection. Engages, through its ectodomain, extracellular matrix components such as hyaluronan/HA, collagen, growth factors, cytokines or proteases and serves as a platform for signal transduction by assembling, via its cytoplasmic domain, protein complexes containing receptor kinases and membrane proteases. Such effectors include PKN2, the RhoGTPases RAC1 and RHOA, Rho-kinases and phospholipase C that coordinate signaling pathways promoting calcium mobilization and actin-mediated cytoskeleton reorganization essential for cell migration and adhesion. |
Protein Name | Cd44 Antigen Cdw44 Epican Extracellular Matrix Receptor Iii Ecmr-Iii Gp90 Lymphocyte Homing/Adhesion Receptor Hutch-I Heparan Sulfate Proteoglycan Hermes Antigen Hyaluronate Receptor Phagocytic Glycoprotein 1 Pgp-1 Phagocytic Glycoprotein I Pgp-I Cd Antigen Cd44 |
Database Links | Reactome: R-HSA-1474228 Reactome: R-HSA-202733 Reactome: R-HSA-216083 Reactome: R-HSA-2160916 Reactome: R-HSA-6798695 Reactome: R-HSA-877300 |
Cellular Localisation | Cell Membrane Single-Pass Type I Membrane Protein Cell Projection Microvillus Secreted Colocalizes With Actin In Membrane Protrusions At Wounding Edges Co-Localizes With Rdx Ezr And Msn In Microvilli Localizes To Cholesterol-Rich Membrane-Bound Lipid Raft Domains |
Alternative Antibody Names | Anti-Cd44 Antigen antibody Anti-Cdw44 antibody Anti-Epican antibody Anti-Extracellular Matrix Receptor Iii antibody Anti-Ecmr-Iii antibody Anti-Gp90 Lymphocyte Homing/Adhesion Receptor antibody Anti-Hutch-I antibody Anti-Heparan Sulfate Proteoglycan antibody Anti-Hermes Antigen antibody Anti-Hyaluronate Receptor antibody Anti-Phagocytic Glycoprotein 1 antibody Anti-Pgp-1 antibody Anti-Phagocytic Glycoprotein I antibody Anti-Pgp-I antibody Anti-Cd Antigen Cd44 antibody Anti-CD44 antibody Anti-LHR antibody Anti-MDU2 antibody Anti-MDU3 antibody Anti-MIC4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance