General Info
| Host: | Mouse |
| Applications: | ICC/IHC-F/FC/WB |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Mouse monoclonal antibody anti-MDR is suitable for use in Immunocytochemistry, Immunohistochemistry, Flow Cytometry and Western Blot research applications. |
| Clonality: | Monoclonal |
| Clone ID: | M2I-4 |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Formulation: | Serum free tissue culture supernatant with 07% BSA and 0.1% sodium azide |
| Concentration: | 250 ug/mL |
| Dilution Range: | ICCIHC-F 1:20FCWB 1:20 |
| Storage Instruction: | Store at 2-8°C upon receipt. |
Information
| Immunogen: | cMOAB/MRP2 amino acids 215-310 |
Description
| Background | M2I-4 reacts with an internal epitope of cMOAT/MRP2, a 170-180 kD transmembrane protein known as the canalicular multi-organic anion transporter, absent in patients with the Dubin-Johnson syndrome, an autosomal recessive liver disorder characterized by chronic conjugated hyperbilirubinemia. cMOAT/MRP2 is closely related to the multidrug resistance related protein MRP, and cMOAT/MRP2 overexpression has been observed in a subset of cisplatin resistant cell lines. M2I-4 was raised against a bacterial fusion protein of cMOAB/MRP2, containing amino acids 215-310 of the protein. M2I-4 did not cross react with the human MDR1, MRP1, MRP3 and MRP5 gene products. |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance