Anti-PDE5A antibody (120-170) {Biotin}

Clonality:	Polyclonal
Conjugation:	Biotin
Isotype:	IgG
Purification:	Affinity Purified
Concentration:	0.55-0.60 µg/µl
Dilution Range:	WB: 1:500-1:1, 000 DB: 1:10, 000 ELISA: 1:10, 000 IP: 1:250 IHC: 1:250 ICC: 1:250 IF: 1:250 CFM: 1:250
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	PDE5A
Gene ID:	8654
Uniprot ID:	PDE5A_HUMAN
Immunogen Region:	120-170
Specificity:	Does not cross-react with other PDE family members.
Immunogen:	Synthetic peptide common to all PDE5A variants taken within amino acid region 120-170 on human PDE5A protein.

Tissue Specificity	Expressed in aortic smooth muscle cells, heart, placenta, skeletal muscle and pancreas and, to a much lesser extent, in brain, liver and lung.
Post Translational Modifications	Phosphorylation is regulated by binding of cGMP to the two allosteric sites. Phosphorylation by PRKG1 leads to its activation.
Function	Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP. Specifically regulates nitric-oxide-generated cGMP.
Protein Name	Cgmp-Specific 3' -5'-Cyclic Phosphodiesterase Cgmp-Binding Cgmp-Specific Phosphodiesterase Cgb-Pde
Database Links	Reactome: R-HSA-418457 Reactome: R-HSA-445355 Reactome: R-HSA-9013422
Alternative Antibody Names	Anti-Cgmp-Specific 3' -5'-Cyclic Phosphodiesterase antibody Anti-Cgmp-Binding Cgmp-Specific Phosphodiesterase antibody Anti-Cgb-Pde antibody Anti-PDE5A antibody Anti-PDE5 antibody

Information sourced from Uniprot.org

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