General Info
| Host: | Rat |
| Applications: | FC |
| Reactivity: | Mouse |
| Note: | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
| Short Description: | Rat monoclonal antibody anti-Integrin alpha-L is suitable for use in Flow Cytometry research applications. |
| Clonality: | Monoclonal |
| Clone ID: | FD441.8 |
| Conjugation: | PE/Cyanine5.5 |
| Isotype: | IgG2bk |
| Formulation: | PBS with 0.05% Proclin300, 1% BSA |
| Concentration: | 0.2 mg/mL |
| Storage Instruction: | Recommend storing between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product. |
Information
| Gene Symbol: | Itgal |
| Gene ID: | 16408 |
| Uniprot ID: | ITAL_MOUSE |
Description
| Tissue Specificity | Leukocytes. |
| Post Translational Modifications | In resting T-cells, up to 40% of surface ITGAL is constitutively phosphorylated. Phosphorylation causes conformational changes needed for ligand binding and is necessary for the activation by some physiological agents. |
| Function | Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is a receptor for F11R. Integrin ITGAL/ITGB2 is a receptor for the secreted form of ubiquitin-like protein ISG15.the interaction is mediated by ITGAL. Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity. Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils. Required for generation of common lymphoid progenitor cells in bone marrow, indicating the role in lymphopoiesis. Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages. |
| Protein Name | Integrin Alpha-LCd11 Antigen-Like Family Member ALeukocyte Adhesion Glycoprotein Lfa-1 Alpha ChainLfa-1aLeukocyte Function-Associated Molecule 1 Alpha ChainLymphocyte Antigen 15Ly-15Cd Antigen Cd11a |
| Database Links | Reactome: R-MMU-198933Reactome: -MMU-202733Reactome: -MMU-216083Reactome: -MMU-6798695 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Integrin Alpha-L antibodyAnti-Cd11 Antigen-Like Family Member A antibodyAnti-Leukocyte Adhesion Glycoprotein Lfa-1 Alpha Chain antibodyAnti-Lfa-1a antibodyAnti-Leukocyte Function-Associated Molecule 1 Alpha Chain antibodyAnti-Lymphocyte Antigen 15 antibodyAnti-Ly-15 antibodyAnti-Cd Antigen Cd11a antibodyAnti-Itgal antibodyAnti-Lfa-1 antibodyAnti-Ly-15 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance