General Info
Host: | Rabbit |
Applications: | ELISA/FRET/ICC/IF/IHC/IP/WB |
Reactivity: | Human/Monkey/Mouse/Rat/Xenopus |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit polyclonal antibody anti-PDE3A is suitable for use in ELISA, FRET, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation and Western Blot research applications. |
Clonality: | Polyclonal |
Conjugation: | Biotin |
Isotype: | IgG |
Purification: | Affinity Purified |
Concentration: | 0.719 µg/µl |
Dilution Range: | WB: 1:500 DB: 1:10, 000 ELISA: 1:10, 000 IP: 1:200 IHC: 1:250 ICC: 1:250 IF: 1:250 CFM: 1:250 |
Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Information
Gene Symbol: | PDE3A |
Gene ID: | 5139 |
Uniprot ID: | PDE3A_HUMAN |
Immunogen: | Synthetic peptide selective only for PDE3A variants |
Description
Function | Cyclic nucleotide phosphodiesterase with specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has also activity toward cUMP. Independently of its catalytic activity it is part of an E2/17beta-estradiol-induced pro-apoptotic signaling pathway. E2 stabilizes the PDE3A/SLFN12 complex in the cytosol, promoting the dephosphorylation of SLFN12 and activating its pro-apoptotic ribosomal RNA/rRNA ribonuclease activity. This apoptotic pathway might be relevant in tissues with high concentration of E2 and be for instance involved in placenta remodeling. |
Protein Name | Cgmp-Inhibited 3' -5'-Cyclic Phosphodiesterase 3a Cyclic Gmp-Inhibited Phosphodiesterase A Cgi-Pde A Cgmp-Inhibited Camp Phosphodiesterase Cgi-Pde |
Database Links | Reactome: R-HSA-418555 |
Cellular Localisation | Membrane Multi-Pass Membrane Protein Cytoplasm Cytosol |
Alternative Antibody Names | Anti-Cgmp-Inhibited 3' -5'-Cyclic Phosphodiesterase 3a antibody Anti-Cyclic Gmp-Inhibited Phosphodiesterase A antibody Anti-Cgi-Pde A antibody Anti-Cgmp-Inhibited Camp Phosphodiesterase antibody Anti-Cgi-Pde antibody Anti-PDE3A antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance