Anti-PDE3A antibody {Biotin}

Clonality:	Polyclonal
Conjugation:	Biotin
Isotype:	IgG
Purification:	Affinity Purified
Concentration:	0.72 µg/µl
Dilution Range:	WB: 1:500 DB: 1:10, 000 ELISA: 1:10, 000 IP: 1:200 IHC: 1:250 ICC: 1:250 IF: 1:250 CFM: 1:250
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	PDE3A
Gene ID:	5139
Uniprot ID:	PDE3A_HUMAN
Immunogen:	Synthetic peptide selective only for PDE3A variants

Function	Cyclic nucleotide phosphodiesterase with specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has also activity toward cUMP. Independently of its catalytic activity it is part of an E2/17beta-estradiol-induced pro-apoptotic signaling pathway. E2 stabilizes the PDE3A/SLFN12 complex in the cytosol, promoting the dephosphorylation of SLFN12 and activating its pro-apoptotic ribosomal RNA/rRNA ribonuclease activity. This apoptotic pathway might be relevant in tissues with high concentration of E2 and be for instance involved in placenta remodeling.
Protein Name	Cgmp-Inhibited 3' -5'-Cyclic Phosphodiesterase 3a Cyclic Gmp-Inhibited Phosphodiesterase A Cgi-Pde A Cgmp-Inhibited Camp Phosphodiesterase Cgi-Pde
Database Links	Reactome: R-HSA-418555
Cellular Localisation	Membrane Multi-Pass Membrane Protein Cytoplasm Cytosol
Alternative Antibody Names	Anti-Cgmp-Inhibited 3' -5'-Cyclic Phosphodiesterase 3a antibody Anti-Cyclic Gmp-Inhibited Phosphodiesterase A antibody Anti-Cgi-Pde A antibody Anti-Cgmp-Inhibited Camp Phosphodiesterase antibody Anti-Cgi-Pde antibody Anti-PDE3A antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance