Reagenti e strumenti per immunologia, biologia cellulare e biologia molecolare
 
> Anti-CD45/Ptprc antibody (Clone: OX-1) {APC}

Anti-CD45/Ptprc antibody (Clone: OX-1) {APC}

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Cat# NB-22-61625-200

Size : 200Tests

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  • Rat splenocytes were stained with Anti-CD45 antibody (filled gray histogram). Unstained splenocytes (empty black histogram) were used as control.

General Info

Host: Mouse
Applications: FC
Reactivity: Rat
Note: FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-Receptor-type tyrosine-protein phosphatase C is suitable for use in Flow Cytometry research applications.
Clonality: Monoclonal
Clone ID: OX-1
Conjugation: APC
Isotype: IgG1k
Formulation: PBS with 0.05% Proclin300, 1% BSA
Storage Instruction: Recommend storing between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product.

Information

Gene Symbol: Ptprc
Gene ID: 24699
Uniprot ID: PTPRC_RAT

Description

Tissue Specificity Isoform 1 and isoform 2 are found in thymocyte and lymph node. Isoform 4 and isoform 3 are found in the lymph nod.
Post Translational Modifications Heavily N- and O-glycosylated. The cytoplasmic domain contains potential phosphorylation sites.
Function Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity.
Protein Name Receptor-Type Tyrosine-Protein Phosphatase C
Leukocyte Common Antigen
L-Ca
T200
Cd Antigen Cd45
Database Links Reactome: R-RNO-202427
Reactome: -RNO-416700
Reactome: -RNO-6798695
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Membrane Raft
Colocalized With Dpp4 In Membrane Rafts
Alternative Antibody Names Anti-Receptor-Type Tyrosine-Protein Phosphatase C antibody
Anti-Leukocyte Common Antigen antibody
Anti-L-Ca antibody
Anti-T200 antibody
Anti-Cd Antigen Cd45 antibody
Anti-Ptprc antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance