General Info
| Host: | Rabbit |
| Applications: | ELISA/IHC/IP/WB |
| Reactivity: | Human/Monkey/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-EAAT1 (480-543) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Biotin |
| Isotype: | IgG |
| Purification: | Affinity Purified |
| Concentration: | 0.61 µg/µl |
| Dilution Range: | WB: 1:500DB: 1:10, 000ELISA: 1:10, 000IP: 1:200IHC: 1:100 |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Information
| Gene Symbol: | Slc1a3 |
| Gene ID: | 20512 |
| Uniprot ID: | EAA1_MOUSE |
| Immunogen Region: | 480-543 |
| Specificity: | Will not cross react with EAAT2 protein. |
| Immunogen: | Synthetic peptide corresponding to C terminal amino acids 480-543 of Mouse EAAT1 protein. The selected peptide was post-synthetically modified to achieve highest antigenicity before coupling to carrier protein using heterobifunctional cross linker fo |
Description
| Tissue Specificity | Detected in brain, in Bergmann glia arborising into the molecular layer of the cerebellum (at protein level). Localized in brain and is highly enriched in the Purkinje cell layer in cerebellum. Intermediate level in lung, low level in spleen, skeletal muscle and testis. |
| Post Translational Modifications | Glycosylated. |
| Function | Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate. Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate. |
| Protein Name | Excitatory Amino Acid Transporter 1Glial High Affinity Glutamate TransporterHigh-Affinity Neuronal Glutamate TransporterGlut-1Sodium-Dependent Glutamate/Aspartate Transporter 1Glast-1Solute Carrier Family 1 Member 3 |
| Database Links | Reactome: R-MMU-210455Reactome: -MMU-210500Reactome: -MMU-425393 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Excitatory Amino Acid Transporter 1 antibodyAnti-Glial High Affinity Glutamate Transporter antibodyAnti-High-Affinity Neuronal Glutamate Transporter antibodyAnti-Glut-1 antibodyAnti-Sodium-Dependent Glutamate/Aspartate Transporter 1 antibodyAnti-Glast-1 antibodyAnti-Solute Carrier Family 1 Member 3 antibodyAnti-Slc1a3 antibodyAnti-Eaat1 antibodyAnti-Gmt1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance