General Info
| Host: | Mouse |
| Applications: | FC/WB/IF/IHC |
| Reactivity: | Cow/Dog/Human/Pig/Rabbit/Sheep |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Mouse monoclonal antibody anti-Keratin 8 is suitable for use in Flow Cytometry, Western Blot, Immunofluorescence and Immunohistochemistry research applications. |
| Clonality: | Monoclonal |
| Clone ID: | C-43 |
| Conjugation: | Unconjugated |
| Isotype: | IgG1k |
| Formulation: | PBS with 0.02% Sodium Azide. |
| Purification: | Affinity purified from tissue culture. |
| Concentration: | Can be provided as 100 µg/mL, 500 µg/mL or 1mg/mL. |
| Dilution Range: | Flow Cytometry (1-2 µg/million cells in 0.1 ml, fix cells in 4% PFA for 10 min, at 4°C, permeabilize with 0, 2% saponin or digitonin for 15 min, at 4°C). Immunoblotting (1-2 µg/ml). Immunofluorescence (1-2 µg/ml). Immunohistology (formalin-fixed: 2-4 |
| Storage Instruction: | Store for up to 1 year at 2-8°C upon receipt. |
Information
| Gene Symbol: | KRTAP10-8 |
| Gene ID: | 386681 |
| Uniprot ID: | KR108_HUMAN |
| Immunogen: | A BALB/c mouse was immunized with a cytoskeleton preparation from HeLa cells. Fusion Partner: Sp2/0. |
Description
| Tissue Specificity | Restricted to a narrow region of the hair fiber cuticle, lying approximately 20 cell layers above the apex of the dermal papilla of the hair root.not detected in any other tissues. |
| Function | In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. |
| Protein Name | Keratin-Associated Protein 10-8High Sulfur Keratin-Associated Protein 10.8Keratin-Associated Protein 10.8Keratin-Associated Protein 18-8Keratin-Associated Protein 18.8 |
| Database Links | Reactome: R-HSA-6805567 |
| Alternative Antibody Names | Anti-Keratin-Associated Protein 10-8 antibodyAnti-High Sulfur Keratin-Associated Protein 10.8 antibodyAnti-Keratin-Associated Protein 10.8 antibodyAnti-Keratin-Associated Protein 18-8 antibodyAnti-Keratin-Associated Protein 18.8 antibodyAnti-KRTAP10-8 antibodyAnti-KAP10.8 antibodyAnti-KAP18-8 antibodyAnti-KRTAP10.8 antibodyAnti-KRTAP18-8 antibodyAnti-KRTAP18.8 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance