General Info
| Host: | Mouse |
| Applications: | FC/WB/IF/IHC |
| Reactivity: | Cat/Cow/Dog/Goat/Human/Pig/Rabbit/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Mouse monoclonal antibody anti-Keratin 17 is suitable for use in Flow Cytometry, Western Blot, Immunofluorescence and Immunohistochemistry research applications. |
| Clonality: | Monoclonal |
| Clone ID: | E3 |
| Conjugation: | Unconjugated |
| Isotype: | IgG2bk |
| Formulation: | PBS with 0.02% Sodium Azide. |
| Purification: | Affinity purified from tissue culture. |
| Concentration: | Can be provided as 100 µg/mL, 500 µg/mL or 1mg/mL. |
| Dilution Range: | Flow Cytometry (0.5-1.0 µg/million cells in 0.1 ml, fix cells in 4% PFA for 10 min, at 4°C, permeabilize with 0, 2% saponin or digitonin for 15 min, at 4°C). Immunoblotting (1 µg/ml for 2h at RT). Immunofluorescence (0.5-1, 0 µg/ml). Immunohistology |
| Storage Instruction: | Store for up to 1 year at 2-8°C upon receipt. |
Information
| Gene Symbol: | Krt17 |
| Gene ID: | 287702 |
| Uniprot ID: | K1C17_RAT |
| Immunogen: | A BALB/c mouse was immunized with an intermediate filament preparation of rat colon mucosa. |
Description
| Post Translational Modifications | Phosphorylation at Ser-44 occurs in a growth- and stress-dependent fashion in skin keratinocytes, it has no effect on filament organization. |
| Function | Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial 'stem cells'. Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors. May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. |
| Protein Name | Keratin - Type I Cytoskeletal 17Cytokeratin-17Ck-17Keratin-17K17Type I Keratin Ka17 |
| Database Links | Reactome: R-RNO-6805567Reactome: -RNO-6809371 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Keratin - Type I Cytoskeletal 17 antibodyAnti-Cytokeratin-17 antibodyAnti-Ck-17 antibodyAnti-Keratin-17 antibodyAnti-K17 antibodyAnti-Type I Keratin Ka17 antibodyAnti-Krt17 antibodyAnti-Ka17 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance