General Info
| Host: | Mouse |
| Applications: | WB |
| Reactivity: | Mouse/Hamster |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Mouse monoclonal antibody anti-Serine protease HTRA2, mitochondrial is suitable for use in Western Blot research applications. |
| Clonality: | Monoclonal |
| Clone ID: | 1H8-C12-F8 |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:1000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Information
| Gene Symbol: | HTRA2 |
| Gene ID: | 27429 |
| Uniprot ID: | HTRA2_HUMAN |
| Specificity: | This antibody detects endogenous levels of HtrA2/Omi and does not cross-react with related proteins. |
| Immunogen: | Recombinant human HtrA2/Omi protein. |
Description
| Post Translational Modifications | Ubiquitinated by BIRC6.this activity is inhibited by DIABLO/SMAC. Autoproteolytically activated. |
| Function | Isoform 1: Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes apoptosis by either relieving the inhibition of BIRC proteins on caspases, leading to an increase in caspase activity.or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves BIRC6 and relieves its inhibition on CASP3, CASP7 and CASP9, but it is also prone to inhibition by BIRC6. Cleaves THAP5 and promotes its degradation during apoptosis. Isoform 2: Seems to be proteolytically inactive. |
| Protein Name | Serine Protease Htra2 - Mitochondrial High Temperature Requirement Protein A2 Htra2 Omi Stress-Regulated Endoprotease Serine Protease 25 Serine Proteinase Omi |
| Database Links | Reactome: R-HSA-9837999 |
| Cellular Localisation | Mitochondrion Intermembrane Space Mitochondrion Membrane Single-Pass Membrane Protein Predominantly Present In The Intermembrane Space Released Into The Cytosol Following Apoptotic Stimuli Such As Uv Treatment And Stimulation Of Mitochondria With Caspase-8 Truncated Bid/Tbid Isoform 1: Endoplasmic Reticulum |
| Alternative Antibody Names | Anti-Serine Protease Htra2 - Mitochondrial antibody Anti-High Temperature Requirement Protein A2 antibody Anti-Htra2 antibody Anti-Omi Stress-Regulated Endoprotease antibody Anti-Serine Protease 25 antibody Anti-Serine Proteinase Omi antibody Anti-HTRA2 antibody Anti-OMI antibody Anti-PRSS25 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance