Anti-AQP4 antibody (300-323) {Biotin}

Clonality:	Polyclonal
Conjugation:	Biotin
Isotype:	IgG
Purification:	Affinity Purified
Concentration:	0.50-0.62 µg/µl
Dilution Range:	WB: 1:500 ELISA: 1:10, 000 IP: 1:200 IHC: 1:100 ICC: 1:100 IF: 1:100
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	AQP4
Gene ID:	361
Uniprot ID:	AQP4_HUMAN
Immunogen Region:	300-323
Immunogen:	Synthetic peptide taken within amino acid region 300-323 on rat Aquaporin 4 protein.

Tissue Specificity	Detected in skeletal muscle. Detected in stomach, along the glandular base region of the fundic gland (at protein level). Detected in brain, lung and skeletal muscle, and at much lower levels in heart and ovary.
Post Translational Modifications	Phosphorylation by PKC at Ser-180 reduces conductance by 50%. Phosphorylation by PKG at Ser-111 in response to glutamate increases conductance by 40%. Isoform 2: Palmitoylated on its N-terminal region. Isoform 1: Not palmitoylated.
Function	Forms a water-specific channel. Plays an important role in brain water homeostasis and in glymphatic solute transport. Required for a normal rate of water exchange across the blood brain interface. Required for normal levels of cerebrospinal fluid influx into the brain cortex and parenchyma along paravascular spaces that surround penetrating arteries, and for normal drainage of interstitial fluid along paravenous drainage pathways. Thereby, it is required for normal clearance of solutes from the brain interstitial fluid, including soluble beta-amyloid peptides derived from APP. Plays a redundant role in urinary water homeostasis and urinary concentrating ability.
Protein Name	Aquaporin-4 Aqp-4 Mercurial-Insensitive Water Channel Miwc Wch4
Database Links	Reactome: R-HSA-432040 Reactome: R-HSA-432047
Cellular Localisation	Cell Membrane Multi-Pass Membrane Protein Basolateral Cell Membrane Endosome Membrane Sarcolemma Cell Projection Activation Of The Vasopressin Receptor Avpr1a Triggers Aqp4 Phosphorylation At Ser-180 And Promotes Its Internalization From The Cell Membrane Detected On Brain Astrocyte Processes And Astrocyte Endfeet Close To Capillaries
Alternative Antibody Names	Anti-Aquaporin-4 antibody Anti-Aqp-4 antibody Anti-Mercurial-Insensitive Water Channel antibody Anti-Miwc antibody Anti-Wch4 antibody Anti-AQP4 antibody

Information sourced from Uniprot.org

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