General Info
| Host: | Rabbit |
| Applications: | WB/IP |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit monoclonal antibody anti-EGR2 (1-100) is suitable for use in Western Blot and Immunoprecipitation research applications. |
| Clonality: | Monoclonal |
| Clone ID: | S9MR |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:100-1:500IP 1:100-1:500 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Information
| Gene Symbol: | EGR2 |
| Gene ID: | 1959 |
| Uniprot ID: | EGR2_HUMAN |
| Immunogen Region: | 1-100 |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human EGR2 (NP_000390.2). |
| Immunogen Sequence: | MMTAKAVDKIPVTLSGFVHQ LSDNIYPVEDLAATSVTIFP NAELGGPFDQMNGVAGDGMI NIDMTGEKRSLDLPYPSSFA PVSAPRNQTFTYMGKFSIDP |
Description
| Post Translational Modifications | Ubiquitinated by WWP2 leading to proteasomal degradation. Acetylated at Lys-247. May be deacetylated by HDAC6, HDAC10 or SIRT1. |
| Function | Sequence-specific DNA-binding transcription factor. Plays a role in hindbrain segmentation by regulating the expression of a subset of homeobox containing genes and in Schwann cell myelination by regulating the expression of genes involved in the formation and maintenance of myelin. Binds to two EGR2-consensus sites EGR2A (5'-CTGTAGGAG-3') and EGR2B (5'-ATGTAGGTG-3') in the HOXB3 enhancer and promotes HOXB3 transcriptional activation. Binds to specific DNA sites located in the promoter region of HOXA4, HOXB2 and ERBB2. Regulates hindbrain segmentation by controlling the expression of Hox genes, such as HOXA4, HOXB3 and HOXB2, and thereby specifying odd and even rhombomeres. Promotes the expression of HOXB3 in the rhombomere r5 in the hindbrain. Regulates myelination in the peripheral nervous system after birth, possibly by regulating the expression of myelin proteins, such as MPZ, and by promoting the differentiation of Schwann cells. Involved in the development of the jaw openener musculature, probably by playing a role in its innervation through trigeminal motor neurons. May play a role in adipogenesis, possibly by regulating the expression of CEBPB. E3 SUMO-protein ligase helping SUMO1 conjugation to its coregulators NAB1 and NAB2, whose sumoylation down-regulates EGR2 transcriptional activity. |
| Protein Name | E3 Sumo-Protein Ligase Egr2At591E3 Sumo-Protein Transferase Erg2Early Growth Response Protein 2Egr-2Zinc Finger Protein Krox-20 |
| Database Links | Reactome: R-HSA-381340Reactome: R-HSA-5617472Reactome: R-HSA-9031628Reactome: R-HSA-9619665 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-E3 Sumo-Protein Ligase Egr2 antibodyAnti-At591 antibodyAnti-E3 Sumo-Protein Transferase Erg2 antibodyAnti-Early Growth Response Protein 2 antibodyAnti-Egr-2 antibodyAnti-Zinc Finger Protein Krox-20 antibodyAnti-EGR2 antibodyAnti-KROX20 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance