Anti-TLR3 antibody (650-700) {Biotin}

Clonality:	Polyclonal
Conjugation:	Biotin
Isotype:	IgG
Purification:	Affinity Purified
Concentration:	0.65-0.77 µg/µl
Dilution Range:	WB: 1:500 ELISA: 1:20, 000 IP: 1:200 IHC: 1:100
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	TLR3
Gene ID:	7098
Uniprot ID:	TLR3_HUMAN
Immunogen Region:	650-700
Immunogen:	Synthetic peptide taken within amino acid region 650-700 on human TLR3 protein.

Tissue Specificity	Expressed at high level in placenta and pancreas. Also detected in CD11c+ immature dendritic cells. Only expressed in dendritic cells and not in other leukocytes, including monocyte precursors. TLR3 is the TLR that is expressed most strongly in the brain, especially in astrocytes, glia, and neurons.
Post Translational Modifications	Heavily N-glycosylated, except on that part of the surface of the ectodomain that is involved in ligand binding. TLR3 signaling requires a proteolytic cleavage mediated by cathepsins CTSB and CTSH, the cleavage occurs between amino acids 252 and 346. The cleaved form of TLR3 is the predominant form found in endosomes. Ubiquitinated by TRIM3.leading to recognition and sorting of polyubiquitinated TLR3 by the ESCRT complexes. Ubiquitinated by ZNRF1 via 'Lys-63'-linked ubiquitin chains.leading to TLR3 lysosomal trafficking and degradation.
Function	Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response.
Protein Name	Toll-Like Receptor 3 Cd Antigen Cd283
Database Links	Reactome: R-HSA-1679131 Reactome: R-HSA-168164 Reactome: R-HSA-168927 Reactome: R-HSA-1810476 Reactome: R-HSA-5602410 Reactome: R-HSA-5602415 Reactome: R-HSA-5602566 Reactome: R-HSA-5602571 Reactome: R-HSA-9013957 Reactome: R-HSA-9013973 Reactome: R-HSA-9014325
Cellular Localisation	Endoplasmic Reticulum Membrane Single-Pass Type I Membrane Protein Endosome Membrane Early Endosome
Alternative Antibody Names	Anti-Toll-Like Receptor 3 antibody Anti-Cd Antigen Cd283 antibody Anti-TLR3 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance