General Info
| Host: | Mouse |
| Applications: | FC |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Mouse monoclonal antibody anti-CD3 is suitable for use in Flow Cytometry research applications. |
| Clonality: | Monoclonal |
| Clone ID: | MEM-57 |
| Conjugation: | PE |
| Isotype: | IgG2ak |
| Formulation: | Stabilizing phosphate buffered saline (PBS) solution containing 15 mM sodium azide |
| Dilution Range: | FC analysis of human blood cells using 20 µl reagent/100 µlwhole blood. |
| Storage Instruction: | Store at 2-8°C upon receipt. |
Information
| Immunogen: | Human thymocytes and T lymphocytes. |
Description
| Background | CD3 complex is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules. This association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation. The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkynje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases. |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance