General Info
| Host: | Mouse |
| Applications: | IHC-P |
| Reactivity: | Human/Dog/Rat/Pig/Sheep |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Mouse monoclonal antibody anti-CD326 is suitable for use in Immunohistochemistry research applications. |
| Clonality: | Monoclonal |
| Clone ID: | BS14 |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Formulation: | TRIS with 0.03% sodium azide, pH7, 2 |
| Dilution Range: | IHC-P 1:100-1:400 |
| Storage Instruction: | Store at 2-8°C upon receipt. |
Information
Description
| Background | Epithelial Cell Adhesion Molecule (EpCAM) is a 40 kDa cell surface antigen and this protein is expressed in almost all epithelial cell membranes but not on mesodermal or neural cell membranes. EpCAM is a Type 1 transmembrane glycoprotein and it is expressed on the basolateral membrane of cells by the majority of epithelial tissues, with the exception of adult squamous epithelium and some specific epithelial cell types including hepatocytes and gastric epithelial cells. EpCAM expression has been reported to be a possible marker of early malignancy, with expression being increased in tumor cells, and de novo expression being seen in dysplastic squamous epithelium. This cell surface, glycosylated 40kD protein is highly expressed in the bone marrow, colon, lung, and most normal epithelial cells and is expressed on carcinomas of gastrointestinal origin. |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance