Anti-TPCN1 antibody {Biotin}

Clonality:	Polyclonal
Conjugation:	Biotin
Isotype:	IgG
Purification:	Affinity Purified
Concentration:	0.55 µg/µl
Dilution Range:	WB: 1:500 DB: 1:10, 000 ELISA: 1:10, 000
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	TPCN1
Gene ID:	53373
Uniprot ID:	TPC1_HUMAN
Immunogen:	Synthetic peptide taken within TMD7 and TMD8 on human TPC1 protein.

Tissue Specificity	Highest expression found in the heart and kidney, and lowest expression found in the spleen.
Post Translational Modifications	N-glycosylated.
Function	Intracellular channel initially characterized as a non-selective Ca(2+)-permeable channel activated by NAADP (nicotinic acid adenine dinucleotide phosphate), it is also a voltage-gated highly-selective Na(+) channel activated directly by PI(3,5)P2 (phosphatidylinositol 3,5-bisphosphate) that senses pH changes and confers electrical excitability to organelles. Localizes to the early and recycling endosomes membranes where it plays a role in the uptake and processing of proteins and regulates organellar membrane excitability, membrane trafficking and pH homeostasis (Probable). Ion selectivity is not fixed but rather agonist-dependent and under defined ionic conditions, can be readily activated by both NAADP and PI(3,5)P2 (Probable). Required for mTOR-dependent nutrient sensing (Probable). (Microbial infection) During Ebola virus (EBOV) infection, controls the movement of endosomes containing virus particles and is required by EBOV to escape from the endosomal network into the cell cytoplasm.
Protein Name	Two Pore Channel Protein 1 Two Pore Calcium Channel Protein 1 Voltage-Dependent Calcium Channel Protein Tpc1
Database Links	Reactome: R-HSA-2672351
Cellular Localisation	Lysosome Membrane Multi-Pass Membrane Protein Endosome Membrane Early Endosome Membrane Recycling Endosome Membrane
Alternative Antibody Names	Anti-Two Pore Channel Protein 1 antibody Anti-Two Pore Calcium Channel Protein 1 antibody Anti-Voltage-Dependent Calcium Channel Protein Tpc1 antibody Anti-TPCN1 antibody Anti-KIAA1169 antibody Anti-TPC1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance