Mouse PGLYRP1 (Peptidoglycan Recognition Protein 1) Sandwich ELISA Kit Ready-To-Use

Storage Instruction:	The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	3 hrs

Gene Symbol:	Pglyrp1
Gene ID:	21946
Uniprot ID:	PGRP1_MOUSE
Immunogen Region:	Ready-To-Use
Sample Type:	serum, plasma, tissue homogenates or other biological fluids.

Tissue Specificity	Strongly expressed in spleen and lung. Also detected in brain and thymus. In the lung, expressed in the intraalveolar space, in the brain, expressed in the Purkinje cells of the cerebellum and in certain layers of neurons in the hippocampus. Also detected in cells filling the space within the intestinal villus.
Post Translational Modifications
Function	Innate immunity protein that plays several important functions in antimicrobial and antitumor defense systems. Acts as a pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria and thus provides bactericidal activity. Forms an equimolar complex with heat shock protein HSPA1A and induces programmed cell death through apoptosis and necroptosis in tumor cell lines by activating the TNFR1 receptor on the target cell membrane. In addition, acts in complex with the Ca(2+)-binding protein S100A4 as a chemoattractant able to induce lymphocyte movement. Mechanistically, this complex acts as a ligand of the chemotactic receptors CCR5 and CXCR3 which are present on the cells of the immune system. Promotes also the activation of lymphocytes that become able to kill virus-infected cells as well as tumor cells by modulating the spectrum of their target-cell specificity. Induction of cytotoxicity on monocyte surface requires interaction with TREM1 receptor.
Protein Name	Peptidoglycan Recognition Protein 1 Cytokine Tag7 Peptidoglycan Recognition Protein Short Pgrp-S
Database Links	Reactome: R-MMU-6798695 Reactome: -MMU-6803157
Cellular Localisation	Cytoplasm Secreted Exists In Both Soluble And Membrane-Associated Forms
Alternative ELISA Names	Peptidoglycan Recognition Protein 1 ELISA kit Cytokine Tag7 ELISA kit Peptidoglycan Recognition Protein Short ELISA kit Pgrp-S ELISA kit Pglyrp1 ELISA kit Pglyrp ELISA kit Pgrp ELISA kit Pgrps ELISA kit Tag7 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance