Anti-TLR1 antibody (370-420) {Biotin}

Clonality:	Polyclonal
Conjugation:	Biotin
Isotype:	IgG
Purification:	Affinity Purified
Concentration:	0.55-0.67 µg/µl
Dilution Range:	WB: 1:500 ELISA: 1:20, 000 IP: 1:200 IHC: 1:100 ICC: 1:100 IF: 1:100
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	TLR1
Gene ID:	7096
Uniprot ID:	TLR1_HUMAN
Immunogen Region:	370-420
Immunogen:	Synthetic peptide taken within amino acid region 370-420 on human Toll-like receptor 1.

Tissue Specificity	Ubiquitous. Highly expressed in spleen, ovary, peripheral blood leukocytes, thymus and small intestine.
Function	Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Forms the activation cluster TLR2:TLR1:CD14 in response to triacylated lipopeptides, this cluster triggers signaling from the cell surface and subsequently is targeted to the Golgi in a lipid-raft dependent pathway. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
Protein Name	Toll-Like Receptor 1 Toll/Interleukin-1 Receptor-Like Protein Til Cd Antigen Cd281
Database Links	Reactome: R-HSA-1236974 Reactome: R-HSA-1461957 Reactome: R-HSA-166058 Reactome: R-HSA-168179 Reactome: R-HSA-5602498 Reactome: R-HSA-5603041 Reactome: R-HSA-5686938 Reactome: R-HSA-9705671
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein Cytoplasmic Vesicle Phagosome Membrane Membrane Raft Golgi Apparatus Does Not Reside In Lipid Rafts Before Stimulation But Accumulates Increasingly In The Raft Upon The Presence Of The Microbial Ligand In Response To Triacylated Lipoproteins Tlr2:Tlr1 Heterodimers Are Recruited In Lipid Rafts This Recruitment Determine The Intracellular Targeting To The Golgi Apparatus
Alternative Antibody Names	Anti-Toll-Like Receptor 1 antibody Anti-Toll/Interleukin-1 Receptor-Like Protein antibody Anti-Til antibody Anti-Cd Antigen Cd281 antibody Anti-TLR1 antibody Anti-KIAA0012 antibody

Information sourced from Uniprot.org

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