Anti-CD46 antibody (Clone: MEM-258)

Clonality:	Monoclonal
Clone ID:	MEM-258
Conjugation:	Unconjugated
Isotype:	IgG1
Formulation:	Phosphate buffered saline (PBS) solution with 15 mM sodium azide
Concentration:	1 mg/mL
Storage Instruction:	Store at 2-8°C upon receipt.

Gene Symbol:	CD46
Gene ID:	4179
Uniprot ID:	MCP_HUMAN
Immunogen:	HPB-ALL human T cell line

Tissue Specificity	Expressed by all cells except erythrocytes.
Post Translational Modifications	N-glycosylated on Asn-83.Asn-114 and Asn-273 in most tissues, but probably less N-glycosylated in testis. N-glycosylation on Asn-114 and Asn-273 is required for cytoprotective function. N-glycosylation on Asn-114 is required for Measles virus binding. N-glycosylation on Asn-273 is required for Neisseria binding. N-glycosylation is not required for human adenovirus binding. Extensively O-glycosylated in the Ser/Thr-rich domain. O-glycosylation is required for Neisseria binding but not for Measles virus or human adenovirus binding. In epithelial cells, isoforms B/D/F/H/J/L/3 are phosphorylated by YES1 in response to infection by Neisseria gonorrhoeae.which promotes infectivity. In T-cells, these isoforms may be phosphorylated by LCK.
Function	Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. (Microbial infection) A number of viral and bacterial pathogens seem to bind MCP in order to exploit its immune regulation property and directly induce an immunosuppressive phenotype in T-cells. (Microbial infection) Acts as a receptor for Adenovirus subgroup B2 and Ad3. (Microbial infection) Acts as a receptor for cultured Measles virus. (Microbial infection) Acts as a receptor for Herpesvirus 6/HHV-6. (Microbial infection) May act as a receptor for pathogenic bacteria Neisseria and Streptococcus pyogenes.
Protein Name	Membrane Cofactor Protein Tlx Trophoblast Leukocyte Common Antigen Cd Antigen Cd46
Database Links	Reactome: R-HSA-977606
Cellular Localisation	Cytoplasmic Vesicle Secretory Vesicle Acrosome Inner Membrane Single-Pass Type I Membrane Protein Inner Acrosomal Membrane Of Spermatozoa Internalized Upon Binding Of Measles Virus Herpesvirus 6 Or Neisseria Gonorrhoeae Which Results In An Increased Susceptibility Of Infected Cells To Complement-Mediated Injury In Cancer Cells Or Cells Infected By Neisseria Shedding Leads To A Soluble Peptide
Alternative Antibody Names	Anti-Membrane Cofactor Protein antibody Anti-Tlx antibody Anti-Trophoblast Leukocyte Common Antigen antibody Anti-Cd Antigen Cd46 antibody Anti-CD46 antibody Anti-MCP antibody Anti-MIC10 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance