General Info
| Host: | Rabbit |
| Applications: | DB/ELISA/IP/WB |
| Reactivity: | Chicken/Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-DDX6 (433-483) is suitable for use in Dot Blot, ELISA, Immunoprecipitation and Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Purification: | Affinity Purified |
| Concentration: | 0.68-0.70 µg/µl |
| Dilution Range: | WB: 1:500DB: 1:4, 000ELISA: 1:4, 000IP: 1:150 |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Information
| Gene Symbol: | DDX6 |
| Gene ID: | 1656 |
| Uniprot ID: | DDX6_HUMAN |
| Immunogen Region: | 433-483 |
| Immunogen: | Synthetic peptide taken within amino acid region 433-483 on probable ATP-dependent RNA helicase DDX6 protein. |
Description
| Tissue Specificity | Abundantly expressed in most tissues. |
| Post Translational Modifications | Sumoylated. |
| Function | Essential for the formation of P-bodies, cytosolic membrane-less ribonucleoprotein granules involved in RNA metabolism through the coordinated storage of mRNAs encoding regulatory functions. Plays a role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation. In the process of mRNA degradation, plays a role in mRNA decapping. Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts. |
| Protein Name | Probable Atp-Dependent Rna Helicase Ddx6Atp-Dependent Rna Helicase P54Dead Box Protein 6Oncogene Rck |
| Database Links | Reactome: R-HSA-430039 |
| Cellular Localisation | CytoplasmP-BodyNucleusImported In The Nucleus Via Interaction With Eif4enif1/4e-T Via A Piggy-Back MechanismUpon Cellular StressRelocalizes To Stress Granules |
| Alternative Antibody Names | Anti-Probable Atp-Dependent Rna Helicase Ddx6 antibodyAnti-Atp-Dependent Rna Helicase P54 antibodyAnti-Dead Box Protein 6 antibodyAnti-Oncogene Rck antibodyAnti-DDX6 antibodyAnti-HLR2 antibodyAnti-RCK antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance