Anti-Phospho-KIRREL-p737/738 antibody {FITC}

Clonality:	Polyclonal
Conjugation:	FITC
Isotype:	IgG
Purification:	Affinity Purified
Concentration:	0.45-0.65 µg/µl
Dilution Range:	WB: 1:250 DB: 1:10, 000 ELISA: 1:10, 000 IP: 1:250 IHC: 1:250 ICC: 1:250 IF: 1:250 CFM: 1:250
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	Kirrel1
Gene ID:	170643
Uniprot ID:	KIRR1_MOUSE
Specificity:	Intracelular domain.
Immunogen:	Phosphorylated synthetic peptide with phospo tyrosine 737 and 738 on mouse Kin of IRRE-like protein 1.

Tissue Specificity	Abundantly expressed in kidney. Specifically expressed in podocytes of kidney glomeruli.
Post Translational Modifications	Phosphorylation probably regulates the interaction with NPHS2. Phosphorylated at Tyr-637 and Tyr-638 by FYN, leading to GRB2 binding. N-glycosylated.
Function	Required for proper function of the glomerular filtration barrier. It is involved in the maintenance of a stable podocyte architecture with interdigitating foot processes connected by specialized cell-cell junctions, known as the slit diaphragm. Is a signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1.
Protein Name	Kin Of Irre-Like Protein 1 Kin Of Irregular Chiasm-Like Protein 1 Nephrin-Like Protein 1
Database Links	Reactome: R-MMU-373753
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein Predominantly Located At Podocyte Slit Diaphragm
Alternative Antibody Names	Anti-Kin Of Irre-Like Protein 1 antibody Anti-Kin Of Irregular Chiasm-Like Protein 1 antibody Anti-Nephrin-Like Protein 1 antibody Anti-Kirrel1 antibody Anti-Kirrel antibody Anti-Neph1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance