Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.05% Proclin300, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:1000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	TERT
Gene ID:	7015
Uniprot ID:	TERT_HUMAN
Immunogen Region:	1000-1100
Immunogen:	A synthetic peptide corresponding to a sequence within amino acids 1000-1100 of human TERT (NP_937983.2).
Immunogen Sequence:	NIYKILLLQAYRFHACVLQL PFHQQVWKNPTFFLRVISDT ASLCYSILKAKNAGMSLGAK GAAGPLPSEAVQWLCHQAFL LKLTRHRVTYVPLLGSLRTA Q

Tissue Specificity	Expressed at a high level in thymocyte subpopulations, at an intermediate level in tonsil T-lymphocytes, and at a low to undetectable level in peripheral blood T-lymphocytes.
Post Translational Modifications	Phosphorylation at Tyr-707 under oxidative stress leads to translocation of TERT to the cytoplasm and reduces its antiapoptotic activity. Dephosphorylated by SHP2/PTPN11 leading to nuclear retention. Phosphorylation at Ser-227 by the AKT pathway promotes nuclear location. Phosphorylation at the G2/M phase at Ser-457 by DYRK2 promotes ubiquitination by the EDVP complex and degradation. Ubiquitinated by the EDVP complex, a E3 ligase complex following phosphorylation at Ser-457 by DYRK2. Ubiquitinated leads to proteasomal degradation. (Microbial infection) In case of infection by HIV-1, the EDVP complex is hijacked by HIV-1 via interaction between HIV-1 Vpr and DCAF1/VPRBP, leading to ubiquitination and degradation.
Function	Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nucleotide telomeric repeat unit, 5'-TTAGGG-3'. The catalytic cycle involves primer binding, primer extension and release of product once the template boundary has been reached or nascent product translocation followed by further extension. More active on substrates containing 2 or 3 telomeric repeats. Telomerase activity is regulated by a number of factors including telomerase complex-associated proteins, chaperones and polypeptide modifiers. Modulates Wnt signaling. Plays important roles in aging and antiapoptosis.
Protein Name	Telomerase Reverse Transcriptase Hest2 Telomerase Catalytic Subunit Telomerase-Associated Protein 2 Tp2
Database Links	Reactome: R-HSA-171319 Reactome: R-HSA-201722
Cellular Localisation	Nucleus Nucleolus Nucleoplasm Chromosome Telomere Cytoplasm Pml Body Shuttling Between Nuclear And Cytoplasm Depends On Cell Cycle Phosphorylation States Transformation And Dna Damage Diffuse Localization In The Nucleoplasm Enriched In Nucleoli Of Certain Cell Types Translocated To The Cytoplasm Via Nuclear Pores In A Crm1/Ran-Dependent Manner Involving Oxidative Stress-Mediated Phosphorylation At Tyr-707 Dephosphorylation At This Site By Shp2 Retains Tert In The Nucleus Translocated To The Nucleus By Phosphorylation By Akt
Alternative Antibody Names	Anti-Telomerase Reverse Transcriptase antibody Anti-Hest2 antibody Anti-Telomerase Catalytic Subunit antibody Anti-Telomerase-Associated Protein 2 antibody Anti-Tp2 antibody Anti-TERT antibody Anti-EST2 antibody Anti-TCS1 antibody Anti-TRT antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance